Our Principal Areas of Expertise
Main R&D Areas
Synthetic Chemistry
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Design and synthesis of novel lipids and lipidoids
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Design and synthesis of novel polymers
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Radiolabeled and stable-isotope lipids to support ADME studies
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Synthetic process technology transfer to Contract Research Organization (CRO)
Product Formulation And Scale-up
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Formulation development and optimization using scalable components and processes
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Process characterization and optimization
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Manufacturing process technical transfer to CRO
Analytical And Biophysical Characterization
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Analytical methods development and transfer, including lipid and nucleic acid-specific analyses
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Biophysical characterization including LNP size and size distribution encapsulation, surface charge and pKa, cryo-electron microscopy
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Bioanalytical method development and analyses for LNP components
Preclinical characterization
Pharmacodynamic studies for protein replacement therapeutics
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Reporter gene (e.g. luciferase) expression in vivo by luminescent live-imaging
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Reporter tissue/cell gene expression ex vivo by flow cytometry,luminescence spectroscopy
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Transgene expression by immunohistochemistry/immunocytochemistry
Safety/tolerability studies
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Clinical pathology/histopathology
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Immune response characterization (e.g. complement,
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cytokines/chemokines)
Bioanalytical
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Nucleic acid therapeutic
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LNP components
Research Program Management
We focus on successful management of the research program to meet partner objectives:
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Coordination and execution of Partner Work Plan
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Monitoring budget, resources and timelines
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Regular communication with partner program management team to ensure alignment