LNP Assembly Instrumentation

High Throughput LNP Assembler

Adalid’s proprietary instrumentation enables automated LNP assembly in a high-throughput 96-well format under precisely controlled parameters and conditions.

Increased Process Control

Fully designed, developed, and validated in-house by Adalid, leveraging proprietary know-how and tailored to internal needs.

Assembly Instrumentation Feature Set

Solutions Tailored For You: We apply our expertise  across the entire drug development pipeline

Low Working Volume Sample Loop

Low Working Volume Sample Loop

‍‍Low working volume for screening  (50 µL sample loop injection)

‍Independently controlled, high-precision pumping system for cargo, lipids, and post-dilution solutions with automatic flow rate calibration (0.5 to 30 mL/min).

‍Independent and automated sampling loop for cargo, lipids, and post-dilution solutions for 96-well plates

Precision Assembly Control

Precise control of assembly parameters:

‍Automated monitoring of the assembly process using AI imaging analysis  (1000 FPS).

In-line UV-VIS sensor for automatic calibration of the assembly process

‍Precisely controlled cutting assembly volume (head + tail minimum  volume > 5 µL)

Automatization 
‍

Full integrated control of the systems parameters via software (Flow rates, flow rate ratios, cargo volume, lipid volume, post dilution volume, head-tail cutting parameters by volume, head-tail cutting parameters by time, synchronizing delay times by volumes of cargo, lipid and post-dilution solutions)

Availability, information and services

Originally developed for internal use, the capabilities of our instrument has attracted interest of our partners, including CDMOs and research or academic institutions. In response to positive feedback, we are now working with an experienced instrument manufacturer to bring the platform to the market by the Q2/2026. We are happy to accommodate requests for beta testing the instrument.

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Assembly, Scale-up
and Platform Shifts

Are you a CDMO or do you plan on using an LNP delivery technology as a payload owner? Particle assembly is a crucial step not only in development but also in scale-up and production - and the field is now undergoing a major shift from the technology used in the production of mRNA COVID-19 vaccines.

With our deep understanding of microfluidics applications in nanoparticle formulation, we are happy to discuss the development of the field - and your needs. We are ready to share our insights and we are also very much interested in what you have to say as your needs, priorities and concerns will drive the direction of the formulation instrumentation development.

LNP Assembly Instrumentation